I tend to use Awasu with my right hand on the mouse and the left one the keyboard which has probably subconsciously influenced my choice of keybaord shortcuts
(apologies to all you southpaws).
I click around with the mouse and use ALT-F, C to close a window and ALT-E, A to mark all as read. I zoom around pretty quick like this
You might also want to try using the Workpad to store items you want to read later. CTRL-R